Prognostic Value of Inflammation-based Prognostic Scores in Patients with Colorectal Cancer

Abstract Background Anatomopathological staging is the primary method to determine prognosis of patients with colorectal carcinoma (CRC). However, new tools have been developed that can complement it, such as analysis elevation systemic inflammatory markers. Objective To evaluate impact scores based on markers (the neutrophil-to-lymphocyte ratio [NLR], Glasgow Prognostic Score [GPS], and isolated C-reactive protein [CRP]) in diagnosed CRC submitted potentially curative surgery Hospital de Braga, Portugal, between January 1st, 2005, December 31st, 2010. Methods A retrospective data 426 was performed, a collection several clinico-pathological variables, well levels lymphocytes, neutrophils, albumin CRP, pre- postoperative periods, apply different sample. Results From survival curves, we concluded increased NLR periods present lower cancer-related than normal (preoperative period: 93.7 versus 122 months; p < 0.001; 112 131 = 0.002). Patients also had disease-free 88.0 111 132 In addition, associated higher risk death due (preoperatively: hazard [HR] 2.25; postoperatively: HR 2.18; 0.003). multivariate shows only (ajusted 2.66; 0.002) does so independently remaining variables. Conclusion Regarding applied sample, one most consistently related patients. it would be useful develop prospective study could confirm this relationship.